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I highly doubt it's going to be Ghosts 2. Thing is, this would be Infinity Ward's 3rd attempt to create a new sub-franchise. Modern Warfare 4 could definitely happen. You don't really need to do a prequel like BO4 did, or like what YouTubers are suggesting. Captain Price is alive, and that's all you really need to continue a series like Modern Warfare. Ghost isn't really a "person" per se, it's an alias of a person. So they could technically bring back Ghost anytime they want to.
It could be as simple as bringing back Price as a Master Chief, Ghost as a part of his team, and a bunch of new recruits. Simple. Villian? Make up a new one!